The Chediak-Higashi syndrome: a possible lysosomal disease.
نویسنده
چکیده
AR(;E ANOMALOUS GRANULATIONS in circulating leukocytes and cells of other tissues are a characteristic feature of Chediak-Higashi ( C.FI.) svndrcme)4 In addition to unusual intracellular particles, atie1 ts with this disease manifest partial albinism, photophobia, neurologic deficits, hepatosplenornegalv, lvmphadenopathy, increased susceptibility to viral and bacterial infections, and early death due frequently to malignant lymphoma.57 The giant granules in the white blood cells have l)een the focus of several investiga-
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Chediak-Higashi-syndrome cultured fibroblasts
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عنوان ژورنال:
- Blood
دوره 28 2 شماره
صفحات -
تاریخ انتشار 1966